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All posts by: Dr. Akram Mirzaei

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2024-02-18
in Prostate cancer

Risk Factors for Early Treatment Discontinuation Due to Toxicity Among Patients With Metastatic Castration-resistant Prostate Cancer Receiving Androgen Receptor–targeted Therapy

Risk Factors for Early Treatment Discontinuation Due to Toxicity Among Patients With Metastatic Castration-resistant Prostate Cancer Receiving Androgen Receptor–targeted Therapy Background:  Androgen receptor–targeted therapies (ARTs) improve survival outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC); however, a significant portion of patients discontinue treatment for various reasons including treatment-related toxicity. We aim to describe reasons […]

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Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth
2024-02-05
in Prostate cancer

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth

Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth Prostate cancer is the most common cancer in men and a major cause of cancer-related deaths. The androgen receptor (AR) plays an essential role in the normal growth and development of the prostate gland, as well as in carcinogenesis. The first-line treatments for advanced […]

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Communication between peri-prostatic adipocytes and epithelial cells drives prostate cancer aggressivity in obese men
2024-01-21
in Prostate cancer

Communication between peri-prostatic adipocytes and epithelial cells drives prostate cancer aggressivity in obese men

Communication between peri-prostatic adipocytes and epithelial cells drives prostate cancer aggressivity in obese men Prostate Cancer affects 1-in-6 men in the UK, and obesity 1-in-3, with rates of both increasing. High-fat diet is linked with increased risk of Prostate Cancer death, and volume of peri-prostatic adipose tissue is associated with increased risk of lethal Prostate […]

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Monitoring Glucocorticoid Receptor in plasma derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer
2024-01-16
in Prostate cancer

Monitoring Glucocorticoid Receptor in plasma derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer

Monitoring Glucocorticoid Receptor in plasma derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer Disease progression following androgen ablation was shown to be associated with upregulation of the glucocorticoid receptor. Longitudinal monitoring of glucocorticoid receptor expression in circulating extracellular vehicles may reflect changes in the tumor cell and […]

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Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells
2024-01-15
in Prostate cancer

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells

Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells The incidence of cancer has steadily been rising worldwide with rapid population aging. Prostate cancer is one of the most common cancers in men, with 1.41 million new cases in 2020. […]

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Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies
2023-12-20
in Prostate cancer

Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies

Effect of aspirin on incidence, recurrence, and mortality in prostate cancer patients: integrating evidence from randomized controlled trials and real-world studies Aspirin has been suggested to reduce the risk of cancer. However, previous studies have been inconsistent regarding the relationship between aspirin use and the risk of occurrence of prostate cancer (PCa). The purpose of […]

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Preclinical evaluation of singlet oxygen-cleavable pro-drugs in combination with protoporphyrin IX-photodynamic therapy in an orthotopic rat model of non-muscle-invasive bladder cancer
2023-12-19
in Bladder cancer

Preclinical evaluation of singlet oxygen-cleavable pro-drugs in combination with protoporphyrin IX-photodynamic therapy in an orthotopic rat model of non-muscle-invasive bladder cancer

Preclinical evaluation of singlet oxygen-cleavable pro-drugs in combination with protoporphyrin IX-photodynamic therapy in an orthotopic rat model of non-muscle-invasive bladder cancer Photodynamic therapy (PDT) initially employed red light, which caused some patients to experience permanent bladder contractions. Photodynamic therapy using the FDA-approved drug hex-amino-levulinate (HAL), which produces protoporphyrin IX (PpIX) in the tumor, showed some […]

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Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance
2023-12-16
in Prostate cancer

Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance

Prostate-Specific Membrane Antigen (PSMA) Expression Predicts Need for Early Treatment in Prostate Cancer Patients Managed with Active Surveillance Prostate cancer is the second most common solid tumor and the fifth leading cause of cancer mortality in men worldwide. Currently, many low-risk and early-stage localized Prostate cancer patients do not receive immediate therapy but are monitored […]

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Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression
2023-12-06
in Kidney cancer

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression

Dynamic partitioning of branched-chain amino acids-derived nitrogen supports renal cancer progression Cancer is an ever-evolving disease in which tumor cells are subject to constant changes in nutrient and oxygen availability within the tumor microenvironment. To adapt to different microenvironments during tumor evolution, cancer cells become metabolically flexible, a process orchestrated either directly by metabolites availability […]

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    Detecting creditable urology research centers of the world to increase scientific communications and exchange ideas and bringing modern technology and urology for further scientific activities of Iranian researchers,
    Training urology researchers,
    Finding new methods of diagnosing and treating urologic diseases, esp. urogenital cancers using Nano medicine technology,
    Applying stem-cell in treating urologic diseases,
    Cooperate with relevant national research, executive centers for conducting research in the field of urology,
    Promoting the awareness level of the public on urologic diseases for prevention, early diagnosis, timely treatment and decreasing complications, morbidity and mortality.

    ADDRESS

    Urology Research Center, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave., Tehran, Iran

    PHONE

    (+98) 6634 8560

    EMAIL

    urc@tums.ac.ir