Lenvatinib Plus Pembrolizumab Improves PFS2, OS in Advanced Renal Cell Carcinoma Upfront lenvatinib plus pembrolizumab improves second progression-free survival (PFS2), when compared with sunitinib, in patients with advanced renal cell carcinoma (RCC), according to updated results from the phase 3 CLEAR study. Patients who received lenvatinib plus pembrolizumab also had improved overall survival (OS) after […]
Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma The transformation and mechanism of methionine metabolism of renal cell carcinoma (RCC) under a hypoxic microenvironment is not well understood as yet. This study exemplified that the reprogramming of methionine metabolism and the subsequent glutathione (GSH) synthesis were mediated by […]
Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis Cancer-associated fibroblasts (CAFs) have been shown to play a key role in prostate cancer treatment resistance, but the role of CAFs in the initial course of enzalutamide therapy for prostate cancer remains unclear. Prostate cancer is a common malignancy and the […]
Clinical validation of circulating GDF15/MIC‐1 as a marker of response to docetaxel and survival in men with metastatic castration‐resistant prostate cancer Elevated circulating growth differentiation factor (GDF15/MIC‐1), interleukin 4 (IL4), and IL6 levels were associated with resistance to docetaxel in an exploratory cohort of men with metastatic castration‐resistant prostate cancer. While androgen deprivation therapy is […]
The Safety, Tolerability, and Preliminary Efficacy of a Gemcitabine-releasing Intravesical System (TAR-200) in American Urological Association–defined Intermediate-risk Non–muscle-invasive Bladder Cancer Patients: A Phase 1b Study Bladder cancer represents a significant public health burden, ranking as the sixth most frequently diagnosed cancer and 11th most deadly cancer in the USA, with worldwide incidence rates being highest […]
Response to 2 Induction Courses of Bacillus Calmette-Guèrin Therapy Among Patients with High-Risk Non–Muscle-Invasive Bladder Cancer5-year Follow-Up of a Phase 2 Clinical Trial Bladder cancer is where a growth of abnormal tissue, known as a tumour, develops in the bladder lining. In some cases, the tumour spreads into the bladder muscle. Bladder cancer most often […]
Risk Factors for Early Treatment Discontinuation Due to Toxicity Among Patients With Metastatic Castration-resistant Prostate Cancer Receiving Androgen Receptor–targeted Therapy Background: Androgen receptor–targeted therapies (ARTs) improve survival outcomes in patients with metastatic castration-resistant prostate cancer (mCRPC); however, a significant portion of patients discontinue treatment for various reasons including treatment-related toxicity. We aim to describe reasons […]
Upregulation of GALNT7 in prostate cancer modifies O-glycosylation and promotes tumour growth Prostate cancer is the most common cancer in men and a major cause of cancer-related deaths. The androgen receptor (AR) plays an essential role in the normal growth and development of the prostate gland, as well as in carcinogenesis. The first-line treatments for advanced […]
Communication between peri-prostatic adipocytes and epithelial cells drives prostate cancer aggressivity in obese men Prostate Cancer affects 1-in-6 men in the UK, and obesity 1-in-3, with rates of both increasing. High-fat diet is linked with increased risk of Prostate Cancer death, and volume of peri-prostatic adipose tissue is associated with increased risk of lethal Prostate […]
Monitoring Glucocorticoid Receptor in plasma derived Extracellular Vesicles as a Marker of Resistance to Androgen Receptor Signaling Inhibition in Prostate Cancer Disease progression following androgen ablation was shown to be associated with upregulation of the glucocorticoid receptor. Longitudinal monitoring of glucocorticoid receptor expression in circulating extracellular vehicles may reflect changes in the tumor cell and […]