Lenvatinib Plus Pembrolizumab Improves PFS2, OS in Advanced Renal Cell Carcinoma Upfront lenvatinib plus pembrolizumab improves second progression-free survival (PFS2), when compared with sunitinib, in patients with advanced renal cell carcinoma (RCC), according to updated results from the phase 3 CLEAR study. Patients who received lenvatinib plus pembrolizumab also had improved overall survival (OS) after […]
Blockade LAT1 Mediates Methionine Metabolism to Overcome Oxaliplatin Resistance under Hypoxia in Renal Cell Carcinoma The transformation and mechanism of methionine metabolism of renal cell carcinoma (RCC) under a hypoxic microenvironment is not well understood as yet. This study exemplified that the reprogramming of methionine metabolism and the subsequent glutathione (GSH) synthesis were mediated by […]
First-Line Immuno-Oncology Therapies Up Survival in RCC With Brain Metastases First-line immuno-oncology (IO)-based regimens and intensive focal therapies are associated with significantly prolonged overall survival (OS) among patients with brain metastases from renal cell carcinoma (RCC), new findings suggest. In a real-world study, median OS was 32.7 months for patients who received first-line IO-based combination […]
Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will […]
Erectile Dysfunction Drugs Plus Nitrates Tied to CV Morbidity and Mortality Risk Among men with stable coronary artery disease (CAD), the use of phosphodiesterase-5 inhibitors (PDE5is), or erectile dysfunction drugs, combined with nitrate medication may increase the risk for cardiovascular morbidity and mortality, according to study findings published in the Journal of the American College of […]
Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition Androgen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to […]
Risk for Gout Flares With Initiation of Urate-Lowering Therapy Varies by Drug/Dose The introduction of urate-lowering therapy (ULT) can affect the risk for gout flares, with fewer flares observed when less intensive treatment and flare prophylaxis were used. These study findings were published in Arthritis Care & Research.Researchers conducted a systematic review and meta-analysis to examine […]
Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis Cancer-associated fibroblasts (CAFs) have been shown to play a key role in prostate cancer treatment resistance, but the role of CAFs in the initial course of enzalutamide therapy for prostate cancer remains unclear. Prostate cancer is a common malignancy and the […]
Clinical validation of circulating GDF15/MIC‐1 as a marker of response to docetaxel and survival in men with metastatic castration‐resistant prostate cancer Elevated circulating growth differentiation factor (GDF15/MIC‐1), interleukin 4 (IL4), and IL6 levels were associated with resistance to docetaxel in an exploratory cohort of men with metastatic castration‐resistant prostate cancer. While androgen deprivation therapy is […]
In Vivo Optical Imaging of Bladder Cancer Tissues in an MB49 Bladder Cancer Orthotopic Mouse Model Using the Intravesical or Intravenous Administration of Near-Infrared Fluorescence Probe Abstract Bladder cancer was the twelfth most common cancer worldwide in 2020. Although bladder cancer has been diagnosed using macroscopic techniques, such as white-light cystoscopy and fluorescence blue-light cystoscopy, […]