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Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy
2022-10-22
in Prostate cancer

Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy

Nascent Prostate Cancer Heterogeneity Drives Evolution and Resistance to Intense Hormonal Therapy Patients diagnosed with high risk localized prostate cancer have variable outcomes following surgery. Trials of intense neoadjuvant androgen deprivation therapy (NADT) have shown lower rates of recurrence among patients with minimal residual disease after treatment. The molecular features that distinguish exceptional responders from […]

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Rezvilutamide Bests Bicalutamide in Metastatic Prostate Cancer
2022-10-12
in Prostate cancer

Rezvilutamide Bests Bicalutamide in Metastatic Prostate Cancer

Rezvilutamide Bests Bicalutamide in Metastatic Prostate Cancer In combination with androgen deprivation therapy (ADT), the novel androgen-receptor inhibitor rezvilutamide significantly improved radiographic progression-free survival (PFS) and overall survival (OS) compared with bicalutamide (Casodex) in patients with high-volume, metastatic, hormone-sensitive prostate cancer, the phase III CHART trial showed. Among 654 mostly Asian patients, median radiographic PFS […]

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For Men on ADT, Checking Bone Density May Thwart Fractures
2022-04-03
in Urology

For Men on ADT, Checking Bone Density May Thwart Fractures

For Men on ADT, Checking Bone Density May Thwart Fractures url: https://www.medpagetoday.com/hematologyoncology/prostatecancer/97997 Keywords: bone density, androgen deprivation therapy, prostate cancer Bone density testing in older prostate cancer patients on androgen deprivation therapy (ADT) was significantly associated with a decreased risk for major osteoporotic fractures, but remains little used, a prospective population-based study found. In the […]

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When Is ADT Right for Biochemically Recurrent Prostate Cancer?
2021-08-21
in Prostate cancer

When Is ADT Right for Biochemically Recurrent Prostate Cancer?

When Is ADT Right for Biochemically Recurrent Prostate Cancer? Men with prostate cancer and biochemical recurrence (BCR) who delayed androgen deprivation therapy (ADT) still experienced long survival outcomes, researchers reported. In a retrospective study, men with a prostate-specific antigen doubling time (PSADT) of less than 10 months saw a median metastases-free survival (MFS) of 192 […]

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