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2024-04-13
in Prostate cancer

Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition

Blocking lipid synthesis induces DNA damage in prostate cancer and increases cell death caused by PARP inhibition Androgen deprivation therapy (ADT) is the primary treatment for prostate cancer; however, resistance to ADT invariably develops, leading to castration-resistant prostate cancer (CRPC). Prostate cancer progression is marked by increased de novo synthesis of fatty acids due to […]

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2024-04-06
in Prostate cancer

ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer

ETV4 mediates dosage-dependent prostate tumor initiation and cooperates with p53 loss to generate prostate cancer The mechanisms underlying ETS-driven prostate cancer initiation and progression remain poorly understood due to a lack of model systems that recapitulate this phenotype. We generated a genetically engineered mouse with prostate-specific expression of the ETS factor, ETV4, at lower and […]

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2024-04-01
in Prostate cancer

MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling

MAOA promotes prostate cancer cell perineural invasion through SEMA3C/PlexinA2/NRP1–cMET signaling Perineural invasion (PNI), a pathologic feature defined as cancer cell invasion in, around, and through nerves, is an indicator of poor prognosis and survival in prostate cancer (PC). Despite widespread recognition of the clinical significance of PNI, the molecular mechanisms are largely unknown. Here, we […]

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2024-03-13
in Prostate cancer

Autonomic nerve regulation for prostate cancer: study based on the tissue transcriptional analysis Abstract

Autonomic nerve regulation for prostate cancer: study based on the tissue transcriptional analysis Abstract Background: The whole-body energy metabolism is regulated by autonomic nerves which also play important roles in the regulation of the generation and development of different kinds of cancers. This study is to analyze the expression of autonomic nerve receptors and their relationship […]

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The Calcium-Sensing Receptor is A Marker and Potential Driver of Neuroendocrine Differentiation in Prostate Cancer
2024-03-05
in Prostate cancer

The Calcium-Sensing Receptor is A Marker and Potential Driver of Neuroendocrine Differentiation in Prostate Cancer

The Calcium-Sensing Receptor is A Marker and Potential Driver of Neuroendocrine Differentiation in Prostate Cancer The mechanisms underlying neuroendocrine (NE) differentiation in prostate cancer (PCa) remain mostly uncharacterized. Since a deregulated calcium homeostasis has been reported in neuroendocrine prostate cancer (NEPC), we explored herein the link between NE differentiation and the calcium-sensing receptor (CaSR). CaSR […]

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2024-02-24
in Prostate cancer

Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors

Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors Investigation of Neural Microenvironment in Prostate Cancer in Context of Neural Density, Perineural Invasion, and Neuroendocrine Profile of Tumors Background: Cancer stroma contains the neural compartment with specific components and action. Neural microenvironment processing includes among […]

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2024-02-15
in Prostate cancer

Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread

Neuropeptide Y and its receptors in prostate cancer: associations with cancer invasiveness and perineural spread Purpose Neuropeptide Y (NPY) is a pleiotropic peptide, which is involved in many biological mechanisms important in regulation of cell growth and survival. The aim of this study was a comprehensive analysis of the NPY system in prostate pathology. Methods […]

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2024-02-11
in Prostate cancer

Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer

Improved Outcomes with Enzalutamide in Biochemically Recurrent Prostate Cancer BACKGROUND Patients with prostate cancer who have high-risk biochemical recurrence have an increased risk of progression. The efficacy and safety of enzalutamide plus androgen-deprivation therapy and enzalutamide monotherapy, as compared with androgen-deprivation therapy alone, are unknown. METHODS In this phase 3 trial, we enrolled patients with […]

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2024-02-01
in Prostate cancer

Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer

Therapeutic blocking of VEGF binding to neuropilin-2 diminishes PD-L1 expression to activate antitumor immunity in prostate cancer Prostate cancers are largely unresponsive to immune checkpoint inhibitors (ICIs), and there is strong evidence that programmed death-ligand 1 (PD-L1) expression itself must be inhibited to activate antitumor immunity. Here, we report that neuropilin-2 (NRP2), which functions as […]

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2024-01-27
in Bladder cancer

Sex Differences in Aging Murine Urinary Bladder and Their Influence on the Tumor Immune Microenvironment in a Carcinogen-Induced Model of Bladder Cancer

Sex Differences in Aging Murine Urinary Bladder and Their Influence on the Tumor Immune Microenvironment in a Carcinogen-Induced Model of Bladder Cancer Sex and age-associated differences in the tumor immune microenvironment of non-muscle invasive bladder cancer (NMIBC) are emerging indicators of treatment outcomes. Incidence Rates: Urothelial carcinoma incidence is four times higher in males than […]

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    Detecting creditable urology research centers of the world to increase scientific communications and exchange ideas and bringing modern technology and urology for further scientific activities of Iranian researchers,
    Training urology researchers,
    Finding new methods of diagnosing and treating urologic diseases, esp. urogenital cancers using Nano medicine technology,
    Applying stem-cell in treating urologic diseases,
    Cooperate with relevant national research, executive centers for conducting research in the field of urology,
    Promoting the awareness level of the public on urologic diseases for prevention, early diagnosis, timely treatment and decreasing complications, morbidity and mortality.

    ADDRESS

    Urology Research Center, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave., Tehran, Iran

    PHONE

    (+98) 6634 8560

    EMAIL

    urc@tums.ac.ir