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2024-04-15
in Urology

Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI 

Fibrinolytic-deficiencies predispose hosts to septicemia from a catheter-associated UTI  Catheter-associated urinary tract infections (CAUTIs) are amongst the most common nosocomial infections worldwide and are difficult to treat partly due to development of multidrug-resistance from CAUTI-related pathogens. Importantly, CAUTI often leads to secondary bloodstream infections and death. A major challenge is to predict when patients will […]

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2024-03-04
in Prostate cancer

Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer

Prediction of plasma ctDNA fraction and prognostic implications of liquid biopsy in advanced prostate cancer No consensus strategies exist for prognosticating metastatic castration-resistant prostate cancer (mCRPC). Circulating tumor DNA fraction (ctDNA%) is increasingly reported by commercial and laboratory tests but its utility for risk stratification is unclear. Here, we intersect ctDNA%, treatment outcomes, and clinical […]

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2024-02-19
in Prostate cancer

Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer

Synthetic lethal combination of CHK1 and WEE1 inhibition for treatment of castration-resistant prostate cancer WEE1 and CHEK1 (CHK1) kinases are critical regulators of the G2/M cell cycle checkpoint and DNA damage response pathways. The WEE1 inhibitor AZD1775 and the CHK1 inhibitor SRA737 are in clinical trials for various cancers, but have not been thoroughly examined […]

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2024-01-28
in Bladder cancer

Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation

Urine-derived bladder cancer organoids (urinoids) as a tool for cancer longitudinal response monitoring and therapy adaptation Bladder cancer is one of the most common cancer types worldwide. Generally, research relies on invasive sampling strategies. Here, we generate bladder cancer organoids directly from urine (urinoids). In this project, we establish 12 urinoid lines from 22 patients […]

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Evaluation of predictive factors for i-CLARAS (intraoperative complications in laparoscopic renal and adrenal surgery): a multicentre international retrospective cohort study
2024-01-23
in Urology

Evaluation of predictive factors for i-CLARAS (intraoperative complications in laparoscopic renal and adrenal surgery): a multicentre international retrospective cohort study

Evaluation of predictive factors for i-CLARAS (intraoperative complications in laparoscopic renal and adrenal surgery): a multicentre international retrospective cohort study Abstract: The laparoscopic approach represents the standard of treatment for renal and adrenal diseases, and its use is increasing even outside referral centres. Although most procedures are routinely performed, intraoperative complications do not occur, and […]

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SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer
2024-01-17
in Prostate cancer

SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer

SND1 binds to ERG and promotes tumor growth in genetic mouse models of prostate cancer Comprehensive genome-wide characterization of human malignancies identified many genes that are recurrently altered in cancer. The exact function of these genes in normal cells and in cancer are often poorly understood. However, such knowledge will be necessary in the future […]

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2024-01-12
in Prostate cancer

Untreated hypogonadism and testosterone replacement therapy in hypogonadal men are associated with a decreased risk of subsequent prostate cancer: a population-based study

Untreated hypogonadism and testosterone replacement therapy in hypogonadal men are associated with a decreased risk of subsequent prostate cancer:a population-based study We sought to understand the relationship between hypogonadism and testosterone replacement therapy (TRT) in hypogonadal men on the risk of developing localized and metastatic prostate cancer. We used the Merative MarketScan database of commercial […]

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2023-12-11
in Kidney disease

Gamma‐glutamyl transferase and calculus of kidney incidence: a Mendelian randomization study

Gamma‐glutamyl transferase and calculus of kidney incidence: a Mendelian randomization study Urolithiasis is a common disease in urology. Individuals afflicted with urolithiasis frequently endure symptoms such as chronic pain, hematuria, urinary obstruction, and an increased risk of developing chronic conditions like renal insufficiency, all of which significantly affect their overall quality of life. The development […]

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NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma
2023-11-27
in Kidney cancer

NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma

NUF2 is correlated with a poor prognosis and immune infiltration in clear cell renal cell carcinoma Background Clear cell renal cell carcinoma (ccRCC) is one of the most common malignancies. Recently, immunotherapy has been considered a promising treatment for metastatic ccRCC. NUF2 is a crucial component of the Ndc80 complex. NUF2 can stabilize microtubule attachment […]

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Bladder cancer organoids as a functional system to model different disease stages and therapy response
2023-11-26
in Bladder cancer

Bladder cancer organoids as a functional system to model different disease stages and therapy response

Bladder cancer organoids as a functional system to model different disease stages and therapy response Abstract: Bladder Cancer (BLCa) inter-patient heterogeneity is the primary cause of treatment failure, suggesting that patients could benefit from a more perso- nalized treatment approach. Patient-derived organoids (PDOs) have been successfully used as a functional model for predicting drug response […]

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    Detecting creditable urology research centers of the world to increase scientific communications and exchange ideas and bringing modern technology and urology for further scientific activities of Iranian researchers,
    Training urology researchers,
    Finding new methods of diagnosing and treating urologic diseases, esp. urogenital cancers using Nano medicine technology,
    Applying stem-cell in treating urologic diseases,
    Cooperate with relevant national research, executive centers for conducting research in the field of urology,
    Promoting the awareness level of the public on urologic diseases for prevention, early diagnosis, timely treatment and decreasing complications, morbidity and mortality.

    ADDRESS

    Urology Research Center, Sina Hospital, Hassan Abad Sq., Imam Khomeini Ave., Tehran, Iran

    PHONE

    (+98) 6634 8560

    EMAIL

    urc@tums.ac.ir